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Based on strong research evidence, breastfeeding, prematurity, significant jaundice in a previous sibling, and jaundice noted before discharge from the nursery are the most common risk factors associated with severe hyperbilirubinemia.
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Based on research evaluating benefit versus harm, jaundice in the first 24 hours after birth is not physiologic jaundice and needs further evaluation.
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All newborns should undergo a risk assessment for hyperbilirubinemia before discharge from the newborn nursery and have appropriate follow-up evaluation after discharge.
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Visual assessment of jaundice does not assess the TSB reliably; clinicians should check either a TSB or TcB when in doubt.
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The infant's age in hours is used when evaluating and managing bilirubin concentrations.
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